Article

Population based targeted sequencing of 54 candidate genes identifies <i>PALB2</i> as a susceptibility gene for high grade serous ovarian cancer

2019-11-29

Abstract excerpt

<h4>Purpose</h4> The known EOC susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting other susceptibility genes exist. The aim of this study was to evaluate the contribution to ovarian cancer susceptibility of rare deleterious germline variants in a set of candidate genes. <h4>Methods</h4> We sequenced the coding region of 54 candidate genes in 6385 invasive EOC cases an...

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Literature Corpus work: 9310ba23-390c-5b3d-a66f-0dfb817a7d10
DOI: 10.1101/19011924

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