Article
Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.
Journal of medical genetics - 1 May 2021
Song Honglin, Dicks Ed M, Tyrer Jonathan, Intermaggio Maria, Chenevix-Trench Georgia, Bowtell David D, Traficante Nadia, Group Aocs, Brenton James, Goranova Teodora, Hosking Karen, Piskorz Anna, van Oudenhove Elke, Doherty Jen, Harris Holly R, Rossing Mary Anne, Duerst Matthias, Dork Thilo, Bogdanova Natalia V, Modugno Francesmary, Moysich Kirsten, Odunsi Kunle, Ness Roberta, Karlan Beth Y, Lester Jenny, Jensen Allan, Krüger Kjaer Susanne, Høgdall Estrid, Campbell Ian G, Lázaro Conxi, Pujara Miguel Angel, Cunningham Julie, Vierkant Robert, Winham Stacey J, Hildebrandt Michelle, Huff Chad, Li Donghui, Wu Xifeng, Yu Yao, Permuth Jennifer B, Levine Douglas A, Schildkraut Joellen M, Riggan Marjorie J, Berchuck Andrew, Webb Penelope M, Group Opal Study, Cybulski Cezary, Gronwald Jacek, Jakubowska Anna, Lubinski Jan, Alsop Jennifer, Harrington Patricia, Chan Isaac, Menon Usha, Pearce Celeste L, Wu Anna H, de Fazio Anna, Kennedy Catherine J, Goode Ellen, Ramus Susan, Gayther Simon, Pharoah Paul
Abstract excerpt
PURPOSE: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate the contribution to ovarian cancer susceptibility of rare deleterious germline variants in a set of candidate genes. METHODS: We sequenced the coding region of 54 candidate genes in 6385...
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