Article

Exome sequencing identifies<i>HELB</i>as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer

2024-04-03

Abstract excerpt

<h4>Summary</h4> Rare, germline loss-of-function variants in a handful of genes that encode DNA repair proteins have been shown to be associated with epithelial ovarian cancer with a stronger association for the high-grade serous hiostotype. The aim of this study was to collate exome sequencing data from multiple epithelial ovarian cancer case cohorts and controls in order to systematically evaluate the role of co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62400daf-fbc9-5ea0-b099-9003a0700c55
DOI: 10.1101/2024.04.02.24304968

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exome sequencing identifies<i>HELB</i>as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancerDOI 10.1101/2024.04.02.24304968Read

Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer.Semantic proximity Read

Rare Germline Genetic Variants and the Risks of Epithelial Ovarian CancerSemantic proximity Read

Population based targeted sequencing of 54 candidate genes identifies <i>PALB2</i> as a susceptibility gene for high grade serous ovarian cancerSemantic proximity Read

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.Semantic proximity Read

Structural variants at the <i>BRCA1/2</i> loci are a common source of homologous repair deficiency in high grade serous ovarian carcinomaSemantic proximity Read

Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes.Semantic proximity Read

Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian CancerSemantic proximity Read

Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicineSemantic proximity Read

Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival.Semantic proximity Read

Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability.Semantic proximity Read

Genomic analyses of germline and somatic variation in high-grade serous ovarian cancerSemantic proximity Read

The prospect of discovering new biomarkers for ovarian cancer based on current knowledge of susceptibility loci and genetic variation (Review).Semantic proximity Read