Article

A silk-based platform to stabilize phenylalanine ammonia-lyase (PAL) for orally administered enzyme replacement therapy

2022-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Phenylalanine ammonia-lyase (PAL) has gained attention in recent years for the treatment of phenylketonuria (PKU), a genetic disorder that affects ∼1 in 15,000 individuals globally. However, the enzyme is easily degraded by proteases, unstable at room temperature, and is currently administered in PKU patients as daily subcutaneous injections. We report here the stabilization of the PAL from Ana...

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Literature Corpus work: 930a1e0e-e13b-59cd-bb4e-59ae912b75a7
DOI: 10.1101/2022.04.14.488340

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