Article

Mapping brain connections to inflammatory networks in depression identifies sex-specific neuroimmune networks and neurobiological subtypes

2026-08-03

Abstract excerpt

<h4>Background</h4> Major depressive disorder is a heterogeneous psychiatric condition, complicating clinical diagnosis and treatment. Efforts to stratify MDD have led to the utilization of systemic inflammatory and neuroimaging markers. Understanding of the relationship between these markers and how they correspond to depressive symptoms is crucial for identifying personalized metrics to rationally diagnose MDD....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5bcb8f6-e18c-53da-82f4-7abf27d1bb88
DOI: 10.64898/2026.08.01.26359430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping brain connections to inflammatory networks in depression identifies sex-specific neuroimmune networks and neurobiological subtypesDOI 10.64898/2026.08.01.26359430Read

Dysregulation of synaptic-related genes of neuroimmune networks within peripheral blood mononuclear cells in major depressive disorderSemantic proximity Read

Sex-specific and multiomic integration enhance accuracy of peripheral blood biomarkers of major depressive disorderSemantic proximity Read

Dissecting depression symptoms: multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulationSemantic proximity Read

Brain Region-Specific Gene Co-expression Networks Reveal Neuroinflammation and ER Stress Signatures in Major Depressive DisorderSemantic proximity Read

Unique genetic and risk-factor profiles in multimorbidity clusters of depression-related disease trajectories from a study of 1.2 million subjectsSemantic proximity Read

Monocyte Dysregulation Defines an MDD-Specific Transcriptional Signature Closely Linked to Clinical MDD TraitsSemantic proximity Read

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis studySemantic proximity Read

Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive DisorderSemantic proximity Read

ENIGMA MDD: Seven Years of Global Neuroimaging Studies of Major Depression through Worldwide Data SharingSemantic proximity Read

Transcriptional dissection of symptomatic profiles across the brain of men and women with depressionSemantic proximity Read

Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics dataSemantic proximity Read

Mapping heterogeneity in the neuroanatomical correlates of depressionSemantic proximity Read