Article
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Cell - 12 Feb 2015
Bonavita Eduardo, Gentile Stefania, Rubino Marcello, Maina Virginia, Papait Roberto, Kunderfranco Paolo, Greco Carolina, Feruglio Francesca, Molgora Martina, Laface Ilaria, Tartari Silvia, Doni Andrea, Pasqualini Fabio, Barbati Elisa, Basso Gianluca, Galdiero Maria Rosaria, Nebuloni Manuela, Roncalli Massimo, Colombo Piergiuseppe, Laghi Luigi, Lambris John D, Jaillon Sébastien, Garlanda Cecilia, Mantovani Alberto
Abstract excerpt
PTX3 is an essential component of the humoral arm of innate immunity, playing a nonredundant role in resistance against selected microbes and in the regulation of inflammation. PTX3 activates and regulates the Complement cascade by interacting with C1q and with Factor H. PTX3 deficiency was assoc...
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