Article

Acetylcysteine synergizes PD-1 blockers against colorectal cancer progression by promoting TCF1+PD1+CD8+T cell differentiation

2024-06-11

Abstract excerpt

<title>Abstract</title> PD-1 blockade is essential in treating progressive colorectal cancer (CRC). However, some CRC patients do not respond well to immunotherapy, possibly due to the exhaustion of CD8+ T cells in the tumor microenvironment. Acetylcysteine (NAC) can reduce CD8+ T cell exhaustion in vitro and induce their differentiation into long-lasting phenotypes, thus enhancing the an...

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Literature Corpus work: 4ba9cc5f-1c5d-55f6-a642-08697ef7d8af
DOI: 10.21203/rs.3.rs-4458393/v1

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