Article

Siglec-F Protects Against Elastase-induced Lung Inflammation and Emphysema in Mice

2025-09-18

Abstract excerpt

Respiratory surfaces are exposed daily to billions of inhaled particles that could cause injury to alveolar tissues where gas exchange occurs. Accordingly, robust defense is essential but must involve minimal physiologic disruption. Airspace macrophages (AMs) protect lung surfaces while also maintaining tissue integrity through non-inflammatory homeostatic responses in health. However, in chronic obstructive pulmo...

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Literature Corpus work: 92a43f7c-7da9-5b3e-981e-0bf4dcb4111a
DOI: 10.1101/2025.09.16.674299

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