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Article

Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2024

Saito Takuya, Fujino Naoya, Kyogoku Yorihiko, Yamada Mitsuhiro, Okutomo Koji, Ono Yoshinao, Konno Shuichi, Endo Takuto, Itakura Koji, Matsumoto Shuichiro, Sano Hirohito, Aizawa Hiroyuki, Numakura Tadahisa, Onodera Katsuhiro, Okada Yoshinori, Hussell Tracy, Ichinose Masakazu, Sugiura Hisatoshi

Abstract excerpt

Alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. However, subpopulations of AMs participating in chronic inflammation have been poorly characterized. We previously reported that Siglec-1 expression on AMs, which is important for bacteria engulfment, was decreased in COPD. Here, we show that Siglec-1-negative AMs isolated...

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PMID: 38530936
DOI: 10.1152/ajplung.00303.2023

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TNF

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