Article

Generation and MHC class II loading of an endogenous influenza epitope revealed by a T cell receptor-like antibody

2026-06-30

Abstract excerpt

CD4 + T cells coordinate immune responses to infections and cancers and initiate many autoimmune diseases, yet the intracellular pathways that generate the peptide antigens they recognize remain incompletely understood. Progress has been limited in part by the scarcity of reagents that directly detect defined peptide:MHC class II (pMHC-II) complexes. Here, we established an mRNA vaccine-based pipeline to generate...

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Literature Corpus work: 9276e402-c5da-5a04-8121-86a397b46f38
DOI: 10.64898/2026.06.25.734564

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