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A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell <i>INS</i> mRNA in a meta-analysis of single cell RNA sequencing data

2020-12-07

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes is characterized by the autoimmune destruction of insulin secreting β cells. Genetic variations upstream at the insulin ( INS ) locus contribute to ~10% of type 1 diabetes heritable risk. Multiple studies showed an association between rs3842753 C/C genotype and type 1 diabetes susceptibility, but the molecular mechanisms remain unclear. To date, no large-scale studies have looke...

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Literature Corpus work: 925d795c-8136-5cbd-a6fd-764a71d32a77
DOI: 10.1101/2020.12.06.413971

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