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Development of a Novel Anti-CD44 variant 6 Monoclonal Antibody for Multiple Applications against Colorectal Carcinomas

2023-01-09

Abstract excerpt

CD44 is a cell surface glycoprotein, and its isoforms are produced by the alternative splicing with the standard and variant exons. The CD44 variant exon containing isoforms (CD44v) are overexpressed in carcinomas. CD44v6 is one of the CD44v, and its overexpression predicts poor prognosis in colorectal cancer (CRC) patients. CD44v6 plays critical roles in CRC adhesion, proliferation, stemness, invasiveness, and ch...

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Identifiers and source

Literature Corpus work
9250d45a-1781-532a-ac44-c5b2dd8eac75
DOI
10.20944/preprints202301.0153.v1
Open publication

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