Article
Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression.
Cancer research - 15 Oct 1993
Wielenga V J, Heider K H, Offerhaus G J, Adolf G R, van den Berg F M, Ponta H, Herrlich P, Pals S T
Abstract excerpt
Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences...
Topics
- Adenoma
- Antigens, CD
- Biomarkers, Tumor
- Blotting, Southern
- Colon
- Colorectal Neoplasms
- DNA
- DNA, Neoplasm
- Exons
- Gene Expression
- Genetic Variation
- Humans
- Hyaluronan Receptors
- Immunohistochemistry
- Intestinal Mucosa
- Neoplasm Metastasis
- Neoplasm Staging
- Polymerase Chain Reaction