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Article

Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.

Cancer letters - 1 Jan 2017

Luo Jingtao, Hong Yun, Lu Yang, Qiu Songbo, Chaganty Bharat K R, Zhang Lun, Wang Xudong, Li Qiang, Fan Zhen

Abstract excerpt

Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, we investigated how acetyl-CoA carboxylase (ACC), a downstream target of AMPK, rewires cancer...

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Identifiers

PMID: 27693630
DOI: 10.1016/j.canlet.2016.09.020
PMCID: PMC5110372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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