Article

A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell models

2024-12-04

Abstract excerpt

Despite substantial drug discovery investments, the lack of any significant therapeutic advancement in the treatment of glioblastoma (GBM) over the past two decades calls for more innovation in the identification of effective treatments. The inter-and intra-patient heterogeneity of GBM presents significant obstacles to effective clinical progression of novel treatments by contributing to tumour plasticity and rapi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92161ce4-f968-52d3-b595-57d42a171495
DOI: 10.1101/2024.11.27.625719

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell modelsDOI 10.1101/2024.11.27.625719Read

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.Semantic proximity Read

A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem CellsSemantic proximity Read

A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem CellsSemantic proximity Read

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastomaSemantic proximity Read

Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular modelsSemantic proximity Read

Multi-omics and pharmacological characterization of patient-derived glioma cell linesSemantic proximity Read

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell LinesSemantic proximity Read

Exploring Responses of Glioblastoma Patient-Derived Cell Cultures to Drugs Reveals New Therapeutic OpportunitiesSemantic proximity Read

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular SubtypesSemantic proximity Read

Targeting Glioblastoma Cell State Plasticity for Enhanced Therapeutic EfficacySemantic proximity Read

Functional genomics identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomasSemantic proximity Read

A multistep in silico approach identifies potential glioblastoma drug candidates via inclusive molecular targeting of glioblastoma stem cellsSemantic proximity Read