Article

Renoprotective Effects of Montelukast in Sepsis-Induced AKI: Targeting the NF-κB Pathway

2025-07-07

Abstract excerpt

<h4>Background: </h4> Sepsis-associated acute kidney injury is ubiquitous among patients with critical conditions and contributes to high mortality rates. SA-AKI was experimentally elicited in murine models via cecal ligation and puncture. Aims This study aimed to determine the possible protective effects of montelukast on sepsis-induced acute kidney injury in a mouse sepsis model. Methods Albino male Swiss mice (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d89dc34a-c2d4-50db-826b-2f5c6e118222
DOI: 10.12688/f1000research.163164.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Renoprotective Effects of Montelukast in Sepsis-Induced AKI: Targeting the NF-κB PathwayDOI 10.12688/f1000research.163164.1Read

Renoprotective Effects of Montelukast in Sepsis-Induced AKI: Targeting the NF-κB PathwaySemantic proximity Read

USF2 Knockdown Downregulates THBS1 to Inhibit the TGF-β Signaling Pathway and Reduce Pyroptosis in Sepsis-Induced Acute Kidney InjurySemantic proximity Read

Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammationSemantic proximity Read

microRNA-590-3p regulates inflammation and organ dysfunction in sepsis mouse model via the Syap1-mediated TGF-β/Smad signaling pathwaySemantic proximity Read

Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagySemantic proximity Read

Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylationSemantic proximity Read

Psoralen improves sepsis-induced acute lung injury by targeting the Ferroptosis mediated by Nrf2 and the NF-κB signaling in macrophagesSemantic proximity Read

MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathwaySemantic proximity Read

Optimization of a Fresh Fecal Intraperitoneal Injection Sepsis Model and Its Divergent Dynamics from Cecal Ligation and Puncture in MiceSemantic proximity Read

Nitrite Protects Against Cardiac Surgery-Associated Acute Kidney Injury via Inflammation Suppression: Insights from a Rat Cardiopulmonary Bypass ModelSemantic proximity Read

Epigenetic Mechanisms in Sepsis-Associated Acute Kidney InjurySemantic proximity Read

Mitophagy and Ferroptosis in Sepsis-Induced ALI/ARDS: Molecular Mechanisms, Interactions and Therapeutic Prospects of Medicinal PlantsSemantic proximity Read