Article
Vendor effects on murine gut microbiota influence experimental abdominal sepsis.
The Journal of surgical research - 1 May 2017
Hilbert Tobias, Steinhagen Folkert, Senzig Sebastian, Cramer Nina, Bekeredjian-Ding Isabelle, Parcina Marijo, Baumgarten Georg, Hoeft Andreas, Frede Stilla, Boehm Olaf, Klaschik Sven
Abstract excerpt
BACKGROUND: Experimental animal models are indispensable components of preclinical sepsis research. Reproducible results highly rely on defined and invariant baseline conditions. Our hypothesis was that the murine gut microbiota varies among different distributors of laboratory animals and that these variations influence the phenotype of abdominal sepsis derived from a bacterial inoculum model (intraperitoneal...
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