Article

ESRP1 deficiency promotes doxorubicin resistance by modulating alternative splicing of SEPTIN9 and SPTBN1-mediated cytoskeleton organization in breast cancer

2025-09-23

Abstract excerpt

<title>Abstract</title> <p>Background Breast cancer remains one of the most prevalent malignancies among women, with doxorubicin resistance posing a significant challenge that undermines treatment success and survival outcomes. Aberrant alternative splicing (AS), driven by dysregulation or mutations in splicing factors (SFs), is implicated in cancer initiation, progression, and drug resistance. This study aims to...

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Literature Corpus work: 92097f10-7933-54ef-b4a4-a0c8ef8ee4d1
DOI: 10.21203/rs.3.rs-7485233/v1

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