Article

Molecular Characterization of ESR1 Variants in Breast Cancer

2022-03-30

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose:</bold><italic>Estrogen receptor 1</italic> (<italic>ESR1</italic>) mutations and fusions typically arise in patients with hormone receptor-positive breast cancer after aromatase inhibitor therapy, whereby ESR1 is constitutively activated in a ligand-independent manner. These variants can impact treatment response. Herein, we characterize <italic>ESR1</italic> variants amo...

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Literature Corpus work: fd159e68-26c9-5163-aa9e-b2167faef790
DOI: 10.21203/rs.3.rs-1359411/v1

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