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Article

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.

Molecular cell - 21 Jul 2006

Takahashi Hidekazu, McCaffery J Michael, Irizarry Rafael A, Boeke Jef D

Abstract excerpt

Metabolic enzymes rarely regulate informational processes like gene expression. Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, as they are important not only for carbon metabolism but also are shown here to supply the acetyl-CoA for histone acetylation by histone acetyltransferases...

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Source

Identifiers

PMID: 16857587
DOI: 10.1016/j.molcel.2006.05.040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16857587-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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