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Genomic context structures CpG-gene expression direction across human tissues

2026-08-28

Abstract excerpt

<title>Abstract</title> <p>DNA methylation-expression associations have no fixed sign. Prior work showed that eQTM direction can be predicted; we asked instead what makes that direction portable across datasets, genomic loci, and tissues. Across 12 cis-eQTM datasets, positive associations increased systematically with distance from the transcription start site, whereas transcription-factor motif features contribu...

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Literature Corpus work: 91e66648-ee45-51c6-9910-189f9579a444
DOI: 10.21203/rs.3.rs-10835710/v1

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