Article

PharmGScore scores of compound genetic variant burden for psychiatric treatment optimization

2023-06-29

Abstract excerpt

The acceptability of antidepressant drugs partly depends on genetic factors. The list of genes involved in antidepressant response, including Adverse Drug Reactions (ADRs) is broad and contains both drug-metabolizing enzymes (pharmacogenes) and genes involved in pharmacodynamics. Variants in pharmacogenes are traditionally reported in the form of star alleles and are partially annotated with known phenotypic conse...

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Literature Corpus work: 91ce8009-c77a-5158-963b-ddcb27e4cf28
DOI: 10.1101/2023.06.27.23291888

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