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Article

Rare variants in drug target genes contributing to complex diseases, phenome-wide.

Scientific reports - 15 Mar 2018

Verma Shefali Setia, Josyula Navya, Verma Anurag, Zhang Xinyuan, Veturi Yogasudha, Dewey Frederick E, Hartzel Dustin N, Lavage Daniel R, Leader Joe, Ritchie Marylyn D, Pendergrass Sarah A

Abstract excerpt

The DrugBank database consists of ~800 genes that are well characterized drug targets. This list of genes is a useful resource for association testing. For example, loss of function (LOF) genetic variation has the potential to mimic the effect of drugs, and high impact variation in these genes can impact downstream traits. Identifying novel associations between genetic variation in these genes and a range of...

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Identifiers

PMID: 29545597
DOI: 10.1038/s41598-018-22834-4
PMCID: PMC5854600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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