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Article

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.

BMC medical genetics - 1 Jan 2010

Müller Timo D, Brönner Günter, Wandolski Melanie, Carrie Jophia, Nguyen Trang T, Greene Brandon H, Scherag André, Grallert Harald, Vogel Carla Ig, Scherag Susann, Rief Winfried, Wichmann Hans-Erich, Illig Thomas, Schäfer Helmut, Hebebrand Johannes, Hinney Anke

Abstract excerpt

BACKGROUND: The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity. METHODS: We initially assessed associ...

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Identifiers

PMID: 20044928
DOI: 10.1186/1471-2350-11-2
PMCID: PMC2830932

Genes

FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20044928-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.PMID 20044928Read ↗

Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population.Semantic proximity Read ↗

Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level.Semantic proximity Read ↗

Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.Semantic proximity Read ↗

[C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and adipocytokine levels in the morbidly obese].Semantic proximity Read ↗

Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent.Semantic proximity Read ↗

Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.Semantic proximity Read ↗

Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture.Semantic proximity Read ↗

Biomarkers of endocannabinoid system activation in severe obesity.Semantic proximity Read ↗

Racial and sex differences in the polymorphisms of the endocannabinoid receptor genes in obesity.Semantic proximity Read ↗

A Genetic Variant of Fatty Acid Amide Hydrolase (FAAH) Exacerbates Hormone-Mediated Orexigenic Feeding in MiceSemantic proximity Read ↗

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes.Semantic proximity Read ↗

The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women.Semantic proximity Read ↗

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