Article

Integrating Causal Inference into Pharmacovigilance: Target Trial Emulations for Proactive Signal Detection of Atorvastatin Initiation in Medicare Beneficiaries

2026-07-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> Adverse drug events (ADEs) in older adults are a substantial public health burden, yet spontaneous reporting systems detect them poorly owing to underreporting and the lack of a defined population. These limitations are of particular concern for older adults, who are underrepresented in pre-approval trials yet at elevated ADE risk owing to polypharmacy, multimorbidity, and a...

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Literature Corpus work: 4e89c18a-c26e-5062-84bb-462ab74e81d8
DOI: 10.64898/2026.07.01.26356874

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