Back to search

Article

Emulation of placebo-controlled index trials using observational data with cloning, censoring and weighting: Empirical assessment of constraints and credibility

2025-10-29

Abstract excerpt

<h4>Objective</h4> Target trial emulation (TTE) has become a prominent approach to conducting observational effectiveness studies, yet limited attention has been paid to the nuances of emulating placebo-controlled trials in this framework using claims data. As a demonstration, we aimed to expand evidence generated by the TOPCAT trial comparing spironolactone versus placebo in patients with heart failure with pres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b92f94d4-1b2c-53eb-9692-b9368f151ad1
DOI
10.1101/2025.10.20.25337820
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Emulation of placebo-controlled index trials using observational data with cloning, censoring and weighting: Empirical assessment of constraints and credibilityDOI 10.1101/2025.10.20.25337820
The R.O.A.D. to clinical trial emulationSemantic proximity
A plasmode simulation-based bias analysis for residual confounding by unmeasured variables leveraging information-rich subsetsSemantic proximity
Integrating Causal Inference into Pharmacovigilance: Target Trial Emulations for Proactive Signal Detection of Atorvastatin Initiation in Medicare BeneficiariesSemantic proximity
Beyond Signal Detection: Sequential Target Trial Emulations to Confirm Previously Detected Adverse Drug Event Signals for Atorvastatin in Older Medicare BeneficiariesSemantic proximity
Computational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference.Semantic proximity
Target trial emulation for a two-arm, parallel, stratified pragmatic RCT of CABG versus PCI in people with high-risk characteristics requiring myocardial revascularisation (High-Risk REVASC)Semantic proximity
Computational Phenomapping of Randomized Clinical Trials to Enable Assessment of their Real-world Representativeness and Personalized InferenceSemantic proximity
High-Throughput Observational Evidence Generation Using Linked Electronic Health Record and Claims DataSemantic proximity
Data reuse enables cost-efficient randomized trials of medical AI modelsSemantic proximity
Bias amplification of unobserved confounding in pharmacoepidemiological studies using indication-based sampling: there is no free lunch in restricting the sample to those with a particular drug-indicationSemantic proximity
Stratified Covariate-Reconstructed Survival (SCRS): Extending Guyot IPD Reconstruction to Preserve Covariate-Outcome Associations for Population- Adjusted Indirect ComparisonsSemantic proximity
Propensity-score matching with GAN-generated observations from electronic health records: simulation study and application to the evaluation of prone positioning in COVID-19 patients under mechanical ventilationSemantic proximity
Select a neighboring publication to make it the new centre.