Article

The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo

2020-07-28

Abstract excerpt

<h4>ABSTRACT</h4> The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine back to presynaptic terminals to preserve vesicular glycine content. GlyT2 loss-of-function mutations cause Hyperekplexia, a rare neurological disease in which loss of glycinergic neurotransmission causes generalized stiffness and strong motor alte...

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Literature Corpus work: 9186ddf0-cd50-5961-9683-a10aed1780e4
DOI: 10.1101/2020.07.28.224659

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