Article

Ubiquitin ligase LNX1 is a major regulator of glycine recapture by the presynaptic transporter GlyT2

2017-12-15

Abstract excerpt

<h4>ABSTRACT</h4> The neuronal glycine transporter GlyT2 is an essential regulator of glycinergic neurotransmission that recaptures glycine in presynaptic terminals to facilitate quantal transmitter packaging in synaptic vesicles. Alterations in GlyT2 expression or activity result in lower cytosolic glycine levels, emptying glycinergic synaptic vesicles and impairing neurotransmission. Lack of glycinergic neurotr...

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Literature Corpus work: 77691058-8fbf-50b4-a7d7-4f9c53c89fe2
DOI: 10.1101/233213

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