Article

Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer

2022-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic progression and treatment-resistance of breast cancer has been associated with epithelial-mesenchymal-transition including downregulation of E-cadherin ( CDH1 ) expression, which can be initiated by inflammatory mediators such as COX-2. Recently, E-cadherin-mediated, cluster-based metastasis and treatment resistance has become more appreciated, though the mechanisms that maintain E-c...

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Literature Corpus work: 9186244b-1bbe-54c5-b439-a2e6ab95cba7
DOI: 10.1101/2022.01.18.476813

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