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Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis

1 Dec 2022

Abstract excerpt

Background: Activated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence of CF in active state inflicts deleterious heart function effects. Mechanisms underlying this cell state conversion are still not fully disclosed, contributing to a...

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PMID: 36531712
DOI: 10.3389/fcvm.2022.1015473

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