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Article

Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1.

JCI insight - 23 Mar 2026

Murabito Alessandra, Mergiotti Marco, Capurro Valeria, Loffreda Alessia, Li Mingchuan, Peretto Paola, Ren Kai, Raimondi Andrea, Tacchetti Carlo, Diviani Dario, Pedemonte Nicoletta, Hirsch Emilio, Ghigo Alessandra

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated chloride channel, cause cystic fibrosis (CF), the most common life-threatening inherited disorder among White individuals. Current CFTR correctors and potentiators, such as elexacaftor-tezacaftor-ivacaftor (ETI), only partially restore the function of the most prevalent mutant, F508del-CFTR, resulting...

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Identifiers

PMID: 41869727
DOI: 10.1172/jci.insight.198846
PMCID: PMC13043088

Genes

CFTR
PKD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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