Article

Epigenetic modifiers to treat retinal degenerative diseases

2025-05-27

Abstract excerpt

We have previously demonstrated the ability of inhibitors of LSD1 and HDAC1 to block rod degeneration, preserve vision, maintain rod-specific transcripts and downregulate those involved in inflammation, gliosis, and cell death in the rd10 mouse model of Retinitis Pigmentosa (RP). To extend our findings we tested the hypothesis that this effect was due to altered chromatin structure by using a range of inhibitors o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91464c4d-21d6-56c6-9f20-188557823988
DOI: 10.1101/2025.05.22.655558

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic modifiers to treat retinal degenerative diseasesDOI 10.1101/2025.05.22.655558Read

DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 miceSemantic proximity Read

Differential effects of HDAC inhibitors in the <i>Rho</i> <sup>I255d</sup> mouse model for autosomal dominant retinitis pigmentosaSemantic proximity Read

HDAC inhibition ameliorates cone survival in retinitis pigmentosa miceSemantic proximity Read

Advances in Ophthalmic Epigenetics and Implications for Epigenetic Therapies: A ReviewSemantic proximity Read

HDAC inhibition ameliorates cone survival in retinitis pigmentosa miceSemantic proximity Read

Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo EfficacySemantic proximity Read

Navigating the future of retinitis pigmentosa treatments: A comprehensive analysis of therapeutic approaches in rd10 miceSemantic proximity Read

A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa.Semantic proximity Read

Dynamic Patterns of Histone Lysine Methylation in the Developing RetinaSemantic proximity Read

Excessive HDAC activation is critical for neurodegeneration in the rd1 mouseSemantic proximity Read

Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophySemantic proximity Read

Epigenetics in Ocular DiseasesSemantic proximity Read