Article

Differential effects of HDAC inhibitors in the <i>Rho</i> <sup>I255d</sup> mouse model for autosomal dominant retinitis pigmentosa

2025-07-31

Abstract excerpt

Retinitis Pigmentosa (RP) is an inherited neurodegenerative disease which leads to loss of retinal photoreceptors and blindness. Histone deacetylases (HDAC) were previously found to be involved in photoreceptor cell death, and HDAC inhibitors have shown protective effects in animal models for autosomal recessive RP. However, whether HDAC inhibitors can protect photoreceptors in autosomal dominant RP (ADRP) remains...

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Literature Corpus work: 63c760c0-8007-5485-9165-00463055a218
DOI: 10.1101/2025.07.25.666875

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