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Article

Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse

11 Feb 2010

Abstract excerpt

Inherited retinal degenerations, collectively termed retinitis pigmentosa (RP), constitute one of the leading causes of blindness in the developed world. RP is at present untreatable and the underlying neurodegenerative mechanisms are unknown, even though the genetic causes are often established. Acetylation and deacetylation of histones, carried out by histone acetyltransferases (HATs) and histone deacetylases...

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PMID: 21364632
DOI: 10.1038/cddis.2010.4

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