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Article

DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice

22 Feb 2018

Abstract excerpt

Abstract Retinitis pigmentosa (RP) is a group of inherited retinal degenerative diseases causing progressive loss of photoreceptors. Numerous gene mutations are identified to be related with RP, but epigenetic modifications may also be involved in the pathogenesis. Previous studies suggested that both DNA methylation and histone acetylation regulate photoreceptor cell death in RP mouse models. However, the role...

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PMID: 29472543
DOI: 10.1038/s41419-018-0349-8

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