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Article

A Genome-wide Expression Association Analysis Identifies Genes and Pathways Associated with Amyotrophic Lateral Sclerosis.

Cellular and molecular neurobiology - 1 Apr 2018

Du Yanan, Wen Yan, Guo Xiong, Hao Jingcan, Wang Wenyu, He Awen, Fan Qianrui, Li Ping, Liu Li, Liang Xiao, Zhang Feng

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with strong genetic components. To identity novel risk variants for ALS, utilizing the latest genome-wide association studies (GWAS) and eQTL study data, we conducted a genome-wide expression association analysis by summary data-based Mendelian randomization (SMR) method. Summary data were derived from a large-scale GWAS of ALS, involving 12577...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28639078
DOI: 10.1007/s10571-017-0512-2

Genes

GGNBP2
ZNHIT3

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