Article

Guidance for the design and analysis of cell-type specific epigenetic epidemiology studies

2024-11-08

Abstract excerpt

Recent studies on the role of epigenetics in disease have focused on DNA methylation profiled in bulk tissues limiting the detection of the cell-type affected by disease related changes. Advances in isolating homogeneous populations of cells now make it possible to identify DNA methylation differences associated with disease in specific cell-types. Critically, these datasets will require a bespoke analytical frame...

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Literature Corpus work: 911a714e-1158-5284-a7f1-3350ec0ca414
DOI: 10.1101/2024.11.06.621949

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