Article

Patient phenotypes and their relation to TNFα signaling and immune cell composition in critical illness and autoimmune disease

2023-11-01

Abstract excerpt

<h4>Rationale</h4> TNFα inhibitors have shown promise in reducing mortality in hospitalized COVID-19 patients; one hypothesis explaining the limited clinical efficacy is patient heterogeneity in the TNFα pathway. <h4>Methods</h4> We evaluated the effect of TNFα inhibitors in a mouse model of LPS-induced acute lung injury. Using machine learning we attempted predictive enrichment of TNFα signaling in patients wit...

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Literature Corpus work: 517dd4ee-fd05-5abc-ba72-d3fe9e0350f8
DOI: 10.1101/2023.10.30.564631

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