Article

Assessing aneuploidy with repetitive element sequencing

2019-06-05

Abstract excerpt

We report a sensitive PCR-based assay that can detect aneuploidy in samples containing as little as 3 picograms of DNA. Using a single primer pair, we amplified ∼750,000 amplicons distributed throughout the genome Aneuploidy was detected in 49% of liquid biopsies from a total of 883 non-metastatic cancers of eight different types. Combining aneuploidy with somatic mutation detection and eight standard protein biom...

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Literature Corpus work: 90f68570-6080-5dcd-93f9-c90b16178522
DOI: 10.1101/660258

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