Article

Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice

2024-10-09

Abstract excerpt

Bone morphogenetic protein4 (BMP4) plays numerous roles during embryogenesis and can signal either alone as a homodimer, or together with BMP7 as a more active heterodimer. BMPs are generated as inactive precursor proteins that dimerize and are cleaved to generate the bioactive ligand and inactive prodomain fragments. In humans, heterozygous mutations within the prodomain of BMP4 are associated with birth defects....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90ef8343-668b-51bc-81ba-2f59f6b78799
DOI: 10.1101/2024.10.08.617306

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in miceDOI 10.1101/2024.10.08.617306Read

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice.Semantic proximity Read

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesisSemantic proximity Read

The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivoSemantic proximity Read

Bone Morphogenetic Protein (BMP) signaling in development and human diseasesSemantic proximity Read

A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.Semantic proximity Read

Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster.Semantic proximity Read

Site-specific cleavage of BMP4 by furin, PC6, and PC7.Semantic proximity Read

Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish.Semantic proximity Read

Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development.Semantic proximity Read

Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.Semantic proximity Read

Acvr2b receptors transduce all BMP signaling in the zebrafish gastrula and restrict Fibrodysplasia Ossificans Progressiva ACVR1-R206H signaling in a dose-dependent mannerSemantic proximity Read