Article

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

2019-06-28

Abstract excerpt

BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is not known whether these heterodimers signal in vivo. To test this, we generated knock in mice carrying a mutation ( Bmp7 R-GFlag ) that prevents proteolytic activation of the dimerized BMP7 precursor protein. This mutation eliminates the function of BMP7 homodimers and all other BMPs that normally heterodimerize with BMP7. Wh...

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Literature Corpus work: 13dda711-6d85-5ba0-9af5-bc7899a1a1e8
DOI: 10.1101/686758

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