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Article

A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species.

The Journal of general virology - 1 Dec 2006

Hagmaier Kathrin, Stock Nicola, Goodbourn Steve, Wang Lin-Fa, Randall Richard

Abstract excerpt

The V protein of the paramyxovirus Nipah virus (NiV) has been shown to antagonize the interferon (IFN) response in human cells via sequestration of STAT1 and STAT2. This study describes a mutant of the NiV V protein, referred to as V(AAHL), that is unable to antagonize IFN signalling and demonstrates that a single amino acid substitution is responsible for its inactivity. The molecular basis for this was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17098981
DOI: 10.1099/vir.0.82261-0
PMCID: PMC2884973

Genes

STAT1
STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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