Article

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

2023-05-08

Abstract excerpt

The Kv8.1 potassium ion channel encoded by the KCNV1 gene is a “silent” subunit whose biological function is unknown. In ALS patient-derived motor neurons carrying SOD1(A4V) and C9orf72 mutations, its expression is highly reduced, yielding increased vulnerability to cell death without a change in motor neuronal firing. Our data suggests that Kv8.1 modulates Kv2 channel function to impact neuronal metabolism and li...

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Literature Corpus work: 90c08584-3ba1-556f-8ca5-126545f455df
DOI: 10.1101/2023.05.07.539778

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