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Article

Mutant SOD1 protein increases Nav1.3 channel excitability.

Journal of biological physics - 1 Jun 2016

Kubat Öktem Elif, Mruk Karen, Chang Joshua, Akin Ata, Kobertz William R, Brown Robert H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a lethal paralytic disease caused by the degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) are present in ~20% of familial ALS and ~2% of all ALS cases. The most common SOD1 gene mutation in North America is a missense mutation substituting valine for alanine (A4V). In this...

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Identifiers

PMID: 27072680
DOI: 10.1007/s10867-016-9411-x
PMCID: PMC4942418

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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