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Article

An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2017

Zhang Yalan, Ni Weiming, Horwich Arthur L, Kaczmarek Leonard K

Abstract excerpt

Mutations that alter levels of Slack (KCNT1) Na+-activated K+ current produce devastating effects on neuronal development and neuronal function. We now find that Slack currents are rapidly suppressed by oligomers of mutant human Cu/Zn superoxide dismutase 1 (SOD1), which are associated with motor neuron toxicity in an inherited form of amyotrophic lateral sclerosis (ALS). We recorded from bag cell neurons of...

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Source

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Identifiers

PMID: 28119399
DOI: 10.1523/JNEUROSCI.3102-16.2017
PMCID: PMC5338764

Genes

SOD1
KCNT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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