Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease.

Pharmacology & therapeutics - 1 Mar 2016

Ovsepian Saak V, LeBerre Marie, Steuber Volker, O'Leary Valerie B, Leibold Christian, Oliver Dolly J

Abstract excerpt

The diversity of pore-forming subunits of KV1 channels (KV1.1-KV1.8) affords their physiological versatility and predicts a range of functional impairments resulting from genetic aberrations. Curiously, identified so far human neurological conditions associated with dysfunctions of KV1 channels have been linked exclusively to mutations in the KCNA1 gene encoding for the KV1.1 subunit. The absence of phenotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kv1.1 Potassium Channel

Share to Mutation

Share to Protein Subunits

Source

Identifiers

PMID: 26825872
DOI: 10.1016/j.pharmthera.2016.01.005

Genes

KCNA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease.PMID 26825872Read ↗

Kv1.1 Channelopathies: Pathophysiological Mechanisms and Therapeutic Approaches.Semantic proximity Read ↗

Variable K(+) channel subunit dysfunction in inherited mutations of KCNA1.Semantic proximity Read ↗

Clinical Spectrum of KCNA1 Mutations: New Insights into Episodic Ataxia and Epilepsy Comorbidity.Semantic proximity Read ↗

Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function.Semantic proximity Read ↗

Kv1.1 and Kv1.2: similar channels, different seizure models.Semantic proximity Read ↗

<i>KCNMA1</i> -linked channelopathySemantic proximity Read ↗

Novel Genetic Variants Expand the Functional, Molecular and Pathological Diversity of KCNA1 ChannelopathySemantic proximity Read ↗

Novel Genetic Variants Expand the Functional, Molecular, and Pathological Diversity of KCNA1 Channelopathy.Semantic proximity Read ↗

Episodic ataxia type 1: a neuronal potassium channelopathy.Semantic proximity Read ↗

Episodic ataxia type-1 mutations in the Kv1.1 potassium channel display distinct folding and intracellular trafficking properties.Semantic proximity Read ↗

Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2.Semantic proximity Read ↗

Kv3.1 channelopathy: a novel loss-of-function variant and the mechanistic basis of its clinical phenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.