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Article

Kv1.1 Channelopathies: Pathophysiological Mechanisms and Therapeutic Approaches.

International journal of molecular sciences - 22 Apr 2020

D'Adamo Maria Cristina, Liantonio Antonella, Rolland Jean-Francois, Pessia Mauro, Imbrici Paola

Abstract excerpt

Kv1.1 belongs to the Shaker subfamily of voltage-gated potassium channels and acts as a critical regulator of neuronal excitability in the central and peripheral nervous systems. KCNA1 is the only gene that has been associated with episodic ataxia type 1 (EA1), an autosomal dominant disorder characterized by ataxia and myokymia and for which different and variable phenotypes have now been reported. The iterative...

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Identifiers

PMID: 32331416
DOI: 10.3390/ijms21082935
PMCID: PMC7215777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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