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Article

Actinorhodin is a redox-active antibiotic with a complex mode of action against Gram-positive cells.

Molecular microbiology - 1 Nov 2017

Mak Stefanie, Nodwell Justin R

Abstract excerpt

Actinorhodin is a blue-pigmented, redox-active secondary metabolite that is produced by the bacterium Streptomyces coelicolor. Although actinorhodin has been used as a model compound for studying secondary metabolism, its biological activity is not well understood. Indeed, redox-active antibiotics in general have not been widely investigated at the mechanistic level. In this work, we have conducted a...

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PMID: 28906045
DOI: 10.1111/mmi.13837

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