Article

Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients

2025-03-14

Abstract excerpt

Post-operative delirium (POD) is a common complication after surgery especially in elderly patients, characterized by acute disturbances in consciousness and cognition, which negatively impacts long-term outcomes. Effective treatments remain elusive due to the unclear pathophysiology of POD. To address the knowledge gap, we investigated DNA methylation profiles and gene expression changes in brain cells from POD a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c38ce1d-b4db-54b7-a8b3-1c3a44866eb7
DOI: 10.1101/2025.03.13.643155

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery PatientsDOI 10.1101/2025.03.13.643155Read

Epigenetics of post-operative delirium: A genome-wide DNA methylation study of neurosurgery patientsSemantic proximity Read

The genome‐wide DNA methylation profiles among neurosurgery patients with and without post‐operative deliriumSemantic proximity Read

Genome-wide DNA methylation analysis of post-operative delirium with brain, blood, saliva, and buccal samples from neurosurgery patientsSemantic proximity Read

DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative deliriumSemantic proximity Read

Excitation-Inhibition Imbalance Underlies Perioperative Neurocognitive Disorders: A Single-Nucleus Transcriptomic Perspective in Mice HippocampusSemantic proximity Read

Differential DNA Methylation and Delirium After Anesthesia and SurgerySemantic proximity Read

Epigenetics biomarkers of delirium: immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatientsSemantic proximity Read

Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium PatientsSemantic proximity Read

Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With AgingSemantic proximity Read

Whole‐transcriptome sequencing identifies neuroinflammation, metabolism and blood–brain barrier related processes in the hippocampus of aged mice during perioperative periodSemantic proximity Read

Application of Multiple Omics to Understand Postoperative Delirium Pathophysiology in HumansSemantic proximity Read

Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review.Semantic proximity Read