Article

Pro-inflammatory alveolar macrophages associated with allograft dysfunction after lung transplantation

2021-03-04

Abstract excerpt

<h4>Purpose</h4> Lung transplant (LT) recipients experience episodes of immune-mediated acute lung allograft dysfunction (ALAD). We have applied single-cell RNA sequencing (scRNAseq) to bronchoalveolar lavage (BAL) cells of stable and ALAD patients to determine key cellular elements in dysfunctional lung allografts. Our particular focus here is on studying alveolar macrophages (AMs) as scRNAseq enables us to eluc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9026bb86-6f1b-5662-879e-4a668d2f0bd2
DOI: 10.1101/2021.03.03.433654

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pro-inflammatory alveolar macrophages associated with allograft dysfunction after lung transplantationDOI 10.1101/2021.03.03.433654Read

Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantationSemantic proximity Read

Identification of a Rejection Signature and Distinct Inflammatory Alveolar Macrophage Populations Post-lung Transplantation.Semantic proximity Read

Single-Cell RNA Sequencing Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in MouseSemantic proximity Read

Monocytes and Macrophages in Kidney Transplantation and Insights from Single Cell RNA-Seq StudiesSemantic proximity Read

Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airwaysSemantic proximity Read

Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing To Define Immune Cell Chimerism in the Rejecting Kidney Transplant.Semantic proximity Read

Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing to Define Immune Cell Chimerism in the Rejecting Kidney TransplantSemantic proximity Read

Immune landscape in rejection of renal transplantation revealed by high-throughput single-cell RNA sequencingSemantic proximity Read

Distinct fibrotic, epithelial and immune transcriptomic programs in phenotypes of chronic lung allograft dysfunctionSemantic proximity Read

Single-cell analysis reveals a pathogenic cellular module associated with early allograft dysfunction after liver transplantationSemantic proximity Read

Spatial Transcriptomics Using Archived Formalin-Fixed Paraffin-Embedded Core Needle Biopsy Tissues Revealed Unique Transcriptomic Signatures in Kidney Transplant RejectionsSemantic proximity Read

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary diseaseSemantic proximity Read